ATF4 is a key molecule linking food intake and skeletal development.
نویسندگان
چکیده
منابع مشابه
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy*
Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions. We identified two small molecules that significantly reduce age-related deficits in skeletal muscle strength, qualit...
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Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the regulation of skeletal development and bone formation is poorly understood. Investigations of the Atf4(-/-);Col2a1-Atf4 mouse model, in which Atf4 is selectively overexpressed ...
متن کاملATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology Implication for Coffin-Lowry Syndrome
Coffin-Lowry Syndrome (CLS) is an X-linked mental retardation condition associated with skeletal abnormalities. The gene mutated in CLS, RSK2, encodes a growth factor-regulated kinase. However, the cellular and molecular bases of the skeletal abnormalities associated with CLS remain unknown. Here, we show that RSK2 is required for osteoblast differentiation and function. We identify the transcr...
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Background: Food insecurity and hunger not only affect physical health, but also have social and psychological effects. Therefore, providing food security for society is one of the major goals of social and economical development programs. The objective of this study was to determine the prevalence and intensity of food insecurity at North West of Tabriz as a population sample of East Azerb...
متن کامل1 2 3 4 5 6 7 p 53 and ATF 4 Mediate Distinct and Additive Pathways 8 to Skeletal Muscle Atrophy During Limb Immobilization 9 10
24 25 Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well 26 understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two 27 transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we 28 demonstrate that three days of muscle immobilization induces muscle atrophy and increa...
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عنوان ژورنال:
- Journal of musculoskeletal & neuronal interactions
دوره 7 4 شماره
صفحات -
تاریخ انتشار 2007